If a patient has persistently positive nucleic acid amplification tests beyond 30 days, additional testing could include molecular studies (e.g., genomic sequencing) or viral culture, in consultation with an infectious disease specialist.Re-testing for SARS-CoV-2 infection is suggested if symptoms worsen or return after ending isolation and precautions.Loss of taste and smell may persist for weeks or months after recovery and need not delay the end of isolation. Also, if a moderately or severely immunocompromised patient with COVID-19 was symptomatic, there should be resolution of fever for at least 24 hours (without the taking fever-reducing medication) and improvement of other symptoms.Results are negative from at least two consecutive respiratory specimens collected ≥ 24 hours apart (total of two negative specimens) tested using an antigen test or nucleic acid amplification test.The criteria for serial testing to end isolation are:.For these people, CDC recommends an isolation period of at least 20 days, and ending isolation in conjunction with serial testing and consultation with an infectious disease specialist to determine the appropriate duration of isolation and precautions. Moderately or severely immunocompromised patients may remain infectious beyond 20 days.Serial testing prior to ending isolation can be considered in consultation with infectious disease experts.įor people who are moderately or severely immunocompromised (regardless of COVID-19 symptoms or severity):.This may warrant extending the duration of isolation and precautions for up to 20 days after symptom onset (with day 0 being the day symptoms appeared) and after resolution of fever for at least 24 hours (without the taking fever-reducing medications) and improvement of other symptoms. Some people with severe illness (e.g., requiring hospitalization, intensive care, or ventilation support) may remain infectious beyond 10 days.Isolation should continue for at least 10 days after symptom onset (day 0 is the day symptoms appeared, and day 1 is the next full day thereafter).Isolation and precautions can be discontinued 10 days after symptom onset (day 0 is the day symptoms appeared, and day 1 is the next full day thereafter).įor people who are severely ill and not moderately or severely immunocompromised:.Isolation may be shortened to 7 days under certain conditions.įor people who are moderately ill and not moderately or severely immunocompromised: In certain high-risk congregate settings that have high risk of secondary transmission, CDC recommends a 10-day isolation period for residents.People who cannot wear a mask, including children
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